Lane Kiffin returns to Oxford when he leads the No. 7 LSU Tigers against the No. 8 Ole Miss Rebels for an early-season SEC showdown. LSU vs. Ole Miss highlights a loaded Week 3 college football schedule, which also features other marquee matchups like SMU vs. Louisville, Florida State vs. Alabama and Auburn vs. Florida. According to the latest college football odds, LSU is favored by 3-points on the road. The latest college football lines list the over/under for total points scored as 58.5. SportsLine's advanced computer model is projecting a defensive battle in Oxford, backing the Under (58.5) in 59% of its simulations. Claim $200 in bonus bets after making a $5 wager with the latest DraftKings promo code:
The model is also backing SMU (+1.5) to cover the spread against Louisville, while the Over (53.5) hits 55% of the time in Auburn vs. Florida. Other notable Week 3 college football betting lines include UNC vs. Clemson (-3.5), Florida State vs. Alabama (-19.5) and Michigan State vs. Notre Dame (-29.5). Before locking in your Week 3 college football picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model. Bet on college football with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:
The model simulates every FBS game 10,000 times. It is on a 33-21 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal. Anybody following its picks on college football betting sites could have seen strong returns. Claim $365 in bonus bets with a $10 bet by signing up for bet365 Sportsbook here:
Week 3 college football best bets (odds subject to change):
- LSU vs. Ole Miss: Under 58.5 points
- SMU (+1.5) vs. Louisville
- Auburn vs. Florida: Over 53.5 points
Combining the model's three picks into a Week 3 college football parlay would result in a payout of +585 (risk $100 to win $585). Bet it now at FanDuel Sportsbook and get up to $350 in bonus bets:
LSU vs. Ole Miss: Under 58.5 points
Two of college football's most explosive offenses are set to collide when Ole Miss hosts LSU on Saturday night. The Tigers are averaging 586.0 yards per game under Kiffin, which ranks third in the nation. The Rebels, meanwhile, are averaging 41.0 points per game this season, led by Heisman hopeful Trinidad Chmabliss. However, both coaching staffs are extremely familiar with each other's tactics and tendencies, which could disrupt the game's offensive flow. In addition, the Under has hit in three of the last four meetings between these SEC rivals. The SportsLine Projection Model predicts these teams will combine for 52 points on Saturday, helping the Under hit in 59% of simulations. Claim $200 in bonus bets after making a $5 wager with the latest DraftKings promo code:
SMU (+1.5) vs. Louisville
An ACC bout is set to unfold when the No. 23 Louisville Cardinals host the No. 16 SMU Mustangs on Saturday at 3:30 p.m. ET. SMU has won its only two meetings with Louisville, most recently beating the Cardinals 38-6 in 2025. SMU has a veteran quarterback in Kevin Jennings, who's thrown for 767 yards and eight touchdowns already this season. Louisville's defense gave up 488 total yards of offense and 41 points in the season opener against Ole Miss, and SportsLine's model is calling for the Mustangs to go on the road and secure a 26-25 victory, helping SMU cover the spread in 56% of simulations. Bet on college football with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:
Auburn vs. Florida: Over 53.5 points
Florida and Auburn are set to square off for the first time since 2019, when the Tigers welcome the Gators to Jordan-Hare Stadium on Saturday night. Florida's offense has been prolific in its first two games under head coach Jon Sumrall. The Gators are averaging 59.0 points per game, which ranks third in college football. The Tigers' offense clicked in their win over Southern Miss last week, with Auburn recording a 43-8 victory at home. The SportsLine Projection Model predicts these teams will combine for 58 points on Saturday, helping the Over hit in 55% of simulations. Bet it now at FanDuel Sportsbook and get up to $350 in bonus bets:
Want more Week 3 college football picks?
You've seen the model's Week 3 college football best bets for Saturday. Now, get against the spread, total and money line picks for every college football game here, all from the model that's simulated every game 10,000 times.
