The Cleveland Browns will continue to see who wins their quarterback competition when they take on the Buffalo Bills in Week 2 of the 2026 NFL preseason on Saturday afternoon. Buffalo opened its preseason schedule with a 29-14 win over the Carolina Panthers, while Cleveland dropped a 34-10 decision to the Chicago Bears. The Bills, who finished second in the AFC East at 12-5 a year ago, were 5-3 on the road in 2025. The Browns, who finished fourth in the AFC North at 5-12, were 3-6 on their home field. The Browns are starting Shedeur Sanders at quarterback, while Deshaun Watson is expected to see playing time in the second half. Visit our DraftKings promo code review to see their latest offers and get started. Claim the latest DraftKings signup promo now:
Kickoff is at 1 p.m. ET from Huntington Bank Field in Cleveland. The latest Bills vs. Browns odds have Cleveland as 2.5-point favorites, while the over/under for total points scored is 37.5. Before making any Browns vs. Bills picks, be sure to see what Jeff Hochman has to say.
Hochman emerged on the sports betting scene in the 1990s. Today he's one of the nation's most respected and selective handicappers. He's 99-88-3 (+686) over the past five NFL seasons. Anybody following has seen Strong returns!
Now, Hochman has locked in another confident pick for Bills vs. Browns. Anybody following his NFL betting picks at sportsbooks and on betting apps could have seen strong returns.
Now, Hochman has zeroed in on Bills vs. Browns. You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Browns vs. Bills:
Bills vs. Browns spread | Browns -2.5 |
Bills vs. Browns over/under | 37.5 points |
Bills vs. Browns money line | Browns -151, Bills +127 |
Bills vs. Browns picks | |
Bills vs. Browns streaming | Fubo (Try for free) |
Top Bills vs. Browns predictions
Hochman does not expect either offense to light up the scoreboard and is leaning Under 37.5 combined points for over/under betting. The Bills may allow Josh Allen to play a series, but are expected to turn to backups Kyle Allen and Shane Buechele at quarterback. Kyle Allen was sharp last week against Carolina, completing 14 of 16 passes for 108 yards.
Sanders completed six of 11 passes for 79 yards in the loss at Chicago. Davon Booth should get another long look at running back. Against the Bears, he carried four times for 53 yards, including a long of 28. See which team to back at SportsLine.
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How to make Bills vs. Browns picks
Hochman also has found a crucial X-factor that makes one side of the spread a must-back. See what it is at SportsLine.
Who wins Bills vs. Browns on Saturday, and what X-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Bills vs. Browns spread you need to jump, all from the expert who is 99-88-3 (+686) over the past five NFL seasons, and find out.
