It's another loaded slate for NFL betting, with matchups like Cowboys vs. Texans, Rams vs. Eagles, Chiefs vs. Raiders and Lions vs. Panthers on tap. According to the latest Week 4 NFL odds, the Cowboys are 2.5-point underdogs against Houston, despite the Texans entering Sunday's showdown with a 0-3 record. Other notable Week 4 NFL lines include Rams vs. Eagles (+3), Chiefs vs. Raiders (+4.5) and Lions vs. Panthers (+3.5). Bet on every Week 4 NFL game with the latest DraftKings promo code, where new users get $150 in bonus bets after making a $5 wager: 

Below you'll find the NFL betting odds for every Week 4 matchup. You can find the SportsLine Projection Model's NFL betting advice for Week 4 here. Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get $55 as a sign-up bonus:

** Odds provided by DraftKings are subject to change **

Sunday, Oct. 4

Indianapolis Colts vs. Washington Commanders 

Spread: Colts -3.5
Moneyline: Colts (-187), Commanders (+155)
Total: 47

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New England Patriots vs. Buffalo Bills

Spread: Bills -6.5
Moneyline: Bills (-324), Patriots (+258)
Total: 48.5

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Tennessee Titans vs. Baltimore Ravens

Spread: Ravens -11.5
Moneyline: Ravens (-714), Titans (+509)
Total: 43.5

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New York Jets vs. Chicago Bears

Spread: Bears -3
Moneyline: Bears (-156), Jets (+132)
Total: 43

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Jacksonville Jaguars vs. Cincinnati Bengals

Spread: Bengals -2.5
Moneyline: Bengals (-142), Jaguars (+120)
Total: 51.5

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Dallas Cowboys vs. Houston Texans

Spread: Texans -2.5
Moneyline: Texans (-140), Cowboys (+119)
Total: 47.5

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Arizona Cardinals vs. New York Giants

Spread: Cardinals -1
Moneyline: Cardinals (-112), Giants (-106)
Total: 44.5

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Los Angeles Rams vs. Philadelphia Eagles

Spread: Rams -3
Moneyline: Rams (-162), Eagles (+136)
Total: 44

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Green Bay Packers vs. Tampa Bay Buccaneers

Spread: Packers -4
Moneyline: Packers (-188), Buccaneers (+157)
Total: 39.5

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Miami Dolphins vs. Minnesota Vikings

Spread: Vikings -10.5
Moneyline: Vikings (-637), Dolphins (+469)
Total: 38.5

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Kansas City Chiefs vs. Las Vegas Raiders

Spread: Chiefs -4.5
Moneyline: Chiefs (-222), Raiders (+184)
Total: 47.5

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Denver Broncos vs. San Francisco 49ers

Spread: 49ers -2.5
Moneyline: 49ers (-149), Broncos (+125)
Total: 46.5

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Los Angeles Chargers vs. Seattle Seahawks

Spread: Seahawks -7
Moneyline: Seahawks (-334), Chargers (+268)
Total: 43

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Detroit Lions vs. Carolina Panthers

Spread: Lions -3.5
Moneyline: Lions (-193), Panthers (+163)
Total: 50.5

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Monday, Oct. 5

Atlanta Falcons vs. New Orleans Saints 

Spread: Saints -2.5
Moneyline: Saints (-151), Falcons (+127)
Total: 48.5

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