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Boxing legend Mike Tyson will return to the ring on Friday when he faces YouTuber-turned-pro fighter Jake Paul at AT&T Stadium in Arlington, Texas. Tyson is getting set for his first officially sanctioned fight since 2005 and his first fight of any kind since an exhibition in 2020. Paul's professional boxing career began in 2020, and he fought on the same card as Tyson in an exhibition at Staples Center in Los Angeles. Tyson vs. Roy Jones Jr. was scored a split draw, while Paul defeated former basketball player Nate Robinson via a second-round knockout on that card.

The latest Jake Paul vs. Mike Tyson odds from FanDuel list Paul as the -205 favorite (risk $205 to win $100) to win, with Tyson a +164 underdog. A draw is +1000. The over/under for total rounds is 5.5 (-112/-112), while the fight to go the distance is +152. Paul to win by knockout is +150, while Tyson to win by knockout is +230. The Netflix broadcast starts at 8 p.m. ET. Before making any Mike Tyson vs. Jake Paul picks, make sure you see the boxing predictions and betting advice from SportsLine combat expert Brandon Wise.  

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing and mixed martial arts analyst who has consistently provided winning selections for SportsLine members. For the past four years, he has hit numerous boxing selections in big-time matchups.

For example, in March, Wise called a win in Round 1 for Paul (+200) against Ryan Bourland and also advised SportsLine members to take the Under 1.5 rounds (+120). Both bets connected when Paul scored a knockout towards the end of the first round. Anyone who has followed Wise's combat sports picks on boxing betting sites has already seen massive returns as they try to get the latest sportsbook promos for the fight.

Now, with the Paul vs. Tyson fight card approaching, Wise has studied the matchup from every angle and released confident picks for the fight. You can only see his picks and analysis at SportsLine

Mike Tyson vs. Jake Paul predictions  

Wise has analyzed the Jake Paul vs. Mike Tyson bout and is leaning Over 5.5 rounds at -150 odds. Tyson has only been stopped inside the distance twice during his legendary career, so Paul is going to have trouble ending this fight early. On the flipside, Paul has sizable physical advantages due to his age and reach, which will make it equally as challenging for Tyson to record an early knockout.

This is also a unique position for both fighters, as Paul has never fought against a boxing legend, and Tyson is making a return to the ring after many years off. Those factors will encourage both boxers to feel their way into the fight and not go for an early knockout. They are also going to be wearing heavier gloves, giving Wise another reason to expect this bout to last six-plus rounds. See who to pick here

How to make Jake Paul vs. Mike Tyson picks

Wise has also locked in a confident money line pick and a method-of-victory prop bet that could pay out big. He's only sharing his picks and analysis at SportsLine.

Who wins Mike Tyson vs. Jake Paul on November 15, and which Paul vs. Tyson props should you be all over? Visit SportsLine now to see Brandon Wise's best bets for the July 20 bout, all from the CBS combat sports specialist who just called Paul's first-round win in March, and find out.