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The 18th-ranked Florida Gators take on the fifth-ranked Connecticut Huskies in a 2025 Jimmy V Classic matchup on Tuesday night. Florida is coming off a 67-66 loss at Duke on Dec. 2, while UConn cruised to an 83-59 win over East Texas A&M on Friday. The Gators (5-3), who are 0-2 against ranked opponents, are 2-2 on neutral courts in 2025. The Huskies (8-1), who are 3-1 against ranked foes, are 2-0 at neutral sites this season. UConn leads the all-time series 5-2, but Florida rallied from a six-point second-half deficit to earn a 77-75 second-round win in the NCAA Tournament this past March, ending UConn's two-year national championship reign.

Tipoff from Madison Square Garden in New York is set for 9 p.m. ET. UConn is a 4.5-point favorite in the latest Florida vs. UConn odds from SportsLine consensus, while the over/under for total points scored is 145.5. Before making any UConn vs. Florida picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,000 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Florida vs. UConn 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for UConn vs. Florida:

Florida vs. UConn spread:    

UConn -4.5 at DraftKings Sportsbook

Florida vs. UConn over/under:    

145.5 points

Florida vs. UConn money line:    

Florida +173, UConn -210

Florida vs. UConn picks:    

See picks at SportsLine

Florida vs. UConn streaming:

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How to make Florida vs. UConn picks

SportsLine's model is going Over on the total (145.5 points). The over hit in the last meeting between the teams, as they combined for 152 points. 

The model projects Florida to have five players register 11.1 points or more, led by Thomas Haugh's projected 12.8 points. 

The Huskies, meanwhile, are projected to have four players scoring 10.4-plus points, led by Alex Karaban with 13.6 points. The model projects a combined total of 152 points as the Over clears in well over 60% of simulations. You can only see that pick at SportsLine.

So who wins Florida vs. UConn, and which side of the spread hits in well over 60% of the time? Visit SportsLine now to see which side of the Florida vs. UConn spread to back, all from the advanced model was profitable on top-ranked college basketball picks last season, and find out.