Houston vs. Colorado odds, prediction: 2026 college basketball picks for February 28 from proven model

The fifth-ranked Houston Cougars look to get back on track as they host the Colorado Buffaloes on Saturday afternoon. Houston has dropped three straight against the top-15 gauntlet of Kansas, Iowa State and Arizona. The Cougars, however, are 23-5 overall and 11-4 in the Big 12, keeping them in the conversation for a top-two seed in the NCAA Tournament. Colorado is 16-12 (6-9 Big 12). and needs a signature win to jumpstart any hopes of a late-season surge. 

Tipoff from the Fertitta Center is at noon ET. The Cougars are 19.5-point favorites in the latest Houston vs. Colorado odds, while the over/under is 139.5. Before making any Colorado vs. Houston picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and it entered Week 17 on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on a 20-11 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

Now, the model has simulated Houston vs. Colorado 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for Colorado vs. Houston:

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Top Houston vs. Colorado predictions

SportsLine's model is going Over on the total (139.5 points). These teams have trended to the Under this season, but this could be a potential bounce-back game for Houston as the Cougars look to rebuild some momentum after their recent slide. 

Colorado averages more than 80 points per game, but also gives up around 77, so that combination could lead to a high score in this one. The model is 148 combined points as the Over hits 74% of the time. 

How to make Colorado vs. Houston picks

The model also says one side of the spread hits nearly 60% of the time. You can only see that pick at SportsLine.

So who wins Colorado vs. Houston, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.