Iowa State vs. Arizona odds, prediction: 2026 college basketball picks for March 2 from proven model

The No. 2 Arizona Wildcats can clinch the No. 1 seed in the Big 12 with a win over the No. 4 Iowa State Cyclones. Iowa State fell to Texas Tech by a score of  82-73 on the road on Saturday, while Arizona is coming off a 84-61 win over Kansas that same day. The Cyclones (24-5, 11-5 Big 12), who have won seven of the last 10, are 5-4 on the road this season. The Wildcats (27-2, 14-2 Big 12), who have won eight of their last 10, are 15-1 on their home floor. Iowa State can still earn the top seed in the conference tournament if it wins its last two games and Arizona loses its last two games.

Tipoff from McKale Memorial Center in Tucson, Ariz., is set for 9 p.m. ET. Arizona is a 7.5-point favorite in the latest Iowa State vs. Arizona odds from DraftKings Sportsbook, while the over/under for total points scored is 149.5. Before making any Arizona vs. Iowa State picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

New users can target the DraftKings promo code, which offers $200 in bonus bets if your first $5+ bet wins:

The SportsLine Projection Model simulates every college basketball game 10,000 times and it entered Week 17 on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on a 20-11 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

Now, the model has simulated Iowa State vs. Arizona 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for Iowa State vs Arizona:

New users can also check out the latest FanDuel promo code and get $100 in bonus bets at FanDuel if your first $5+ bet wins:

Iowa State vs. Arizona predictions

SportsLine's model is going Over on the total (149.5 points). This is the first matchup between the powerhouses this season. The Cyclones are 9-2-1 ATS in their last 12 games when playing as the underdog. The Wildcats, meanwhile, are 14-2 straight-up in their last 16 games against an opponent in the Big 12 conference.

The model projects the Cyclones to have five players score 13.6 points or more, including Joshua Jefferson, projected to score 16.6 points. The Wildcats are projected to have five players score in double figures, led by Brayden Burries, who is projected to score 14.5 points. The model is projecting 153 combined points as the Over clears in well over 60% of simulations.

How to make Iowa State vs. Arizona picks

The model also says one side of the spread hits in nearly 60% of simulations. You can only see that pick at SportsLine.

So who wins Iowa State vs. Arizona and which side of the spread hits in nearly 60% of simulations? Visit SportsLine now to see which side of the Iowa State vs Arizona spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.