Michigan vs. Ohio State odds, prediction: 2026 Big Ten Tournament quarterfinal picks from proven model

The eighth-seeded Ohio State Buckeyes take on the top-seeded Michigan Wolverines in a 2026 Big Ten Tournament quarterfinal on Friday afternoon. Ohio State is coming off a 72-69 win over Iowa on Thursday, while Michigan closed out its regular-season schedule with a 90-80 win over Michigan State on Sunday. The Buckeyes (21-11), who are 2-7 against ranked opponents, have won four in a row. The Wolverines (29-2), who have won four in a row, are looking to win their second consecutive Big Ten Conference Tournament championship.

Tipoff from the United Center in Chicago is set for noon ET. Michigan leads the all-time series 110-84, including a two-game season sweep of the Buckeyes. Michigan is a 12.5-point favorite in the latest Ohio State vs. Michigan odds from DraftKings Sportsbook, while the over/under for total points scored is 154.5. Before making any Michigan vs. Ohio State picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered conference tournament week on a sizzling 14-2 run on its top-rated over/under college basketball picks dating back to last season, and is on a 28-21 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.    

Now, the model has simulated Ohio State vs. Michigan 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for Michigan vs. Ohio State:

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Top Ohio State vs. Michigan predictions

SportsLine's model is going Over on the total (154.5 points). The Over hit in each of the last four Ohio State games, and in the last Michigan game. Ohio State is 7-3 against the spread in its last 10 games. Michigan, meanwhile, is 5-5 ATS in its last 10.

The model projects the Buckeyes to have five players score 10.4 points or more, including Bruce Thornton, who is projected to score 20.6 points. The Wolverines are projected to have four players score 11.3 points or more, led by Yaxel Lendeborg, who is projected to score 17.8 points. The model is projecting 156 combined points.

How to make Michigan vs. Ohio State picks

The model also says one side of the spread hits in nearly 70% of simulations. You can only see that pick at SportsLine.

So who wins Michigan vs. Ohio State, and which side of the spread hits in nearly 70% of the time? Visit SportsLine now to see which side of the Ohio State vs. Michigan spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.