Ohio State vs. Michigan State prediction, odds, time: 2026 college basketball picks from proven model

SportsLine's model simulated Michigan State vs. Ohio State 10,000 times and revealed its Sunday college basketball picks for their Big Ten matchup on CBS and Paramount+

By Ross Kelly

Feb 22, 2026 at 9:15 am ET • 3 min read

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Longtime Big Ten rivals will meet on Sunday on CBS and Paramount+ when the Michigan St. Spartans host the Ohio State Buckeyes. No. 15 Michigan State (21-5, 11-4 Big Ten) has alternated wins and losses over its last four and is coming off a Tuesday victory over UCLA, 82-59. The Buckeyes (17-9, 9-6 Big Ten) have alternated wins and losses over their last nine games, most recently defeating Wisconsin, 86-69, on Feb. 17. Michigan State leads the all-time series with 44 wins versus 23 losses, but the programs have split their last eight matchups.

Tipoff is at 1 p.m. ET from the Breslin Center in East Lansing, Mich. MSU won the last meeting, 69-62, a year ago. The Spartans are 10.5-point favorites in the latest Ohio State vs. Michigan State odds, while the over/under for total points scored is 147.5. Before making any Michigan State vs. Ohio State college basketball picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 16 on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 13-7 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

Now, the model has simulated Michigan State vs. Ohio State 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for Ohio State vs. Michigan State:

Michigan State vs. Ohio State spread:	Michigan State -10.5 at DraftKings
Michigan State vs. Ohio State over/under:	147.5 points
Michigan State vs. Ohio State money line:	Michigan State -610, Ohio State +440
Michigan State vs. Ohio State picks:	See picks at SportsLine
Michigan State vs. Ohio State streaming:	Paramount+ (sign up here)

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Top Ohio State vs. Michigan State predictions

SportsLine's model has simulated Michigan State vs. Ohio State 10,000 times and is going Over on the total (147.5 points). The Spartans have been on quite a run with the Over, as the total has been surpassed in each of their last six games. Tom Izzo's offensive is highly efficient, with Jeremy Fears Jr. leading the nation in assists (9.3) as Michigan State ranks in the top 10 in the statistic as a team, while ranking outside the top 200 in terms of turnovers committed per game.

Meanwhile, Ohio State's offense is far ahead of its defense as the Buckeyes are in the top 40, nationally, in offensive rating but outside the top 200 in defensive rating. The Buckeyes are forecasted to have the game's two top scorers, but MSU counters with eight players projected to have more than 5 points, twice as many as Ohio State. The model calls for 151 combined points as the total is surpassed in 59.6% of simulations.