Following perhaps its biggest win of the season, Villanova will look to avoid a letdown Wednesday when it hosts stubborn DePaul in a prime-time matchup. The high-powered Wildcats are 19-point favorites, with the over-under for total points scored set at 154.5.

Before making any kind of pick, you need to hear what Kenny White has to say. The pioneering Las Vegas oddsmaker is now a top analyst for SportsLine, and he has been on top of his game as of late.

White is on a 22-13 run in his college basketball ATS selections for SportsLine. He has also been locked in on DePaul, with a 3-0 record when the Blue Demons are involved. Now, he's locked in a pick for Wednesday's game.

White knows the Wildcats (24-3, 11-3) hit a late-season slide with losses to St. John's and Providence in a seven-day span.

But they answered the call Saturday against first-place Xavier in a fight to stay near the top of the Big East. The 95-79 win at Xavier gave Villanova a season sweep over the Musketeers, ended its nine-game winning streak and cut its lead to a half-game in the standings.

Mikal Bridges had 25 points on 10 of 15 shooting to lead all five starters in double-figures. Potential national player of the year Jalen Brunson had 11 points and eight assists.

White also knows the rebuilding Blue Demons (10-16, 3-11) have been a sometimes-dangerous underdog and appear to be improving. Their last three losses have come by seven total points and they have a blowout win at Providence to their credit.

DePaul is coming off an 82-77 loss at Seton Hall that was a two-point game with 30 seconds left. Marin Maric led the way with 23 points.

Will the Wildcats refine their late-season form with a blowout win and cover, or will DePaul catch them in a letdown spot? Visit SportsLine now to find out which side of DePaul-Villanova you should jump on Wednesday, and see which critical stat gives one side a huge edge, all from the handicapper who is on a 22-13 college basketball run.