College football odds, picks, betting lines, spreads: 2025-26 Bowl season predictions

SportsLine's computer model has revealed its college football bowl picks and CFP First Round predictions after 10,000 simulations of each game

By Ross Kelly

Dec 8, 2025 at 1:59 pm ET • 4 min read

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A season which began in late August is reaching its conclusion, with that being the 2025-26 college football bowl schedule. There are 46 FBS bowl games, so there are no shortage of opportunities to make college football bowl bets. The LA Bowl kicks things off on Saturday with Washington vs. Boise State (+8.5), with the CFP First Round starting on Dec. 19. The opener is a matchup of Blue Bloods as Alabama is a 1.5-point road favorite over Oklahoma per the latest college football bowl odds.

That's one of a handful of games with a college football spread of 2 points or fewer. Others include Louisiana vs. Delaware (+2), Arizona State vs. Duke (-1.5) and Navy vs. Cincinnati (-1.5). The largest of the college football bowl spreads comes in the CFP, with Oregon favored by 20.5 points versus James Madison. Other games of interest include powerhouse programs facing off, such as Penn State vs. Clemson (-1.5) in the Pinstripe Bowl and Michigan vs. Texas (-4.5) in the Citrus Bowl. Before locking in any college football bowl picks, be sure to see the latest Championship Week college football predictions from SportsLine's proven model.

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, it has turned its attention to the latest college football odds and 2025-26 bowl season college football betting lines on the spread, money line and over/under. Head here to see every pick.

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Top college football predictions for bowl season

One of the college football picks the model is high on during the 2025-26 college football bowl schedule: Penn State (-1.5, 48.5) covers against Clemson in the Pinstripe Bowl on Saturday, Dec. 27 at noon ET. Both schools vastly underperformed this year but had strong finishes, with each finishing the season 3-1 ATS. However, Dabo Swinney has lost four of his last six bowl games, with each defeat coming by at least 14 points. This year, his Tigers are averaging 28.7 points, which ranks 61st in the nation, while Penn State, despite playing in the much tougher Big Ten, ranks 37th nationally in scoring. Also, the location of this game in New York City favors a northeastern university like Penn State over Clemson from South Carolina. The Nittany Lions cover almost 60% of the time, while the model also says the Under hits in almost 60% of simulations. See which other picks the model likes here.

Another prediction: Missouri (-7, 50.5) covers versus No. 20 Virginia in the Gator Bowl on Dec. 27 in well over 50% of simulations. UVA is coming off an ACC Title Game loss to Duke, in which the Cavaliers would have made the CFP if they had won. Thus, you have to wonder about motivation now that they have to settle for a lesser bowl game, and Virginia has struggled in bowls to begin with, going 1-4 over the last 19 years. Mizzou has won back-to-back bowls under Eli Drinkwitz, and the Tigers' only losses this season came versus teams ranked in the top 10 of the AP Poll at the time. Missouri is 4-1 ATS at neutral sites since Drinkwitz took over in 2020, and the Tigers are 12-4 ATS as favorites since the start of last season. See the rest of the model's picks here.

How to make college football picks for bowl season

The model has also made the call on who wins and covers in every 2025-26 college football bowl game, and it's calling for five underdogs to outright win in bowl matchups of power conference teams. You can only get every pick for every game at SportsLine, and for a limited time you can use promo code CHAMPIONSHIP to get your first month at SportsLine for $1.

So what college football picks can you make with confidence, and which five underdogs are projected to win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.