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An intriguing non-conference matchup features the Memphis Tigers (2-0) going on the road to play the Florida State Seminoles (0-2) on Saturday. The Seminoles lead the all-time series 10-7-1, but this will be the first game since 1990. FSU desperately needs to get in the win column after opening the season with back-to-back upset losses at the hands of ACC foes Georgia Tech and Boston College. Memphis is a contender to represent the Group of Five in the College Football Playoff, and a win over a program like FSU and Mike Norvell, who coached the Tigers from 2016-19, would certainly go a long way.

Kickoff from Bobby Bowden Field at Doak Campbell Stadium in Tallahassee, Fla., is set for noon ET. After opening at -1.5, the Seminoles are 6.5-point favorites in the latest Memphis vs. Florida State odds via SportsLine consensus, while the over/under for total points scored is 53.5. Before making any Florida State vs. Memphis picks, you need to see the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now the model has dialed in on FSU vs. Memphis and just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football odds on the spreadmoney line and over/under for Memphis vs. FSU:

  • Florida State vs. Memphis spread: Seminoles -6.5
  • Florida State vs. Memphis over/under: 53.5 points 
  • Florida State vs. Memphis money line: Seminoles -258, Tigers +208
  • FSU: Florida State has hit the 1Q Game Total Under in nine of its last 13 games
  • MEM: Memphis has hit the 1H Game Total Over in its last five away games
  • Memphis vs. Florida State picks: See picks here

Why Memphis can cover

Memphis has been able to move the ball on the ground, averaging 135 rushing yards per game. Senior running back Mario Anderson is the bellcow in the backfield for the Tigers. Anderson uses his explosiveness and straight-line speed to evade defenders. He's logged 27 carries for 171 yards, and four touchdowns.

In addition, he averages 85.5 rushing yards per game and 6.3 yards per carry. Last week, he logged 125 yards and two touchdowns. Senior receiver Demeer Blankumsee tracks the ball well downfield and impressive elusiveness after the catch. In 2024, the Ohio native notched seven receptions for 96 yards and 13.7 yards per catch. He's notched 45-plus yards in two straight games. See who to back at SportsLine.

Why Florida State can cover

The Seminoles haven't been able to find a groove thus far in the season, but there is still time to turn it around. Senior receiver Ja'khi Douglas has been the most consistent pass catcher. Douglas has excellent short-area quickness which helps him create YAC opportunities with the ball in his hands. The Louisiana native leads the team in both receptions (8) and receiving yards (121) with 15.1 yards per catch. 

In his last outing, Douglas reeled in four catches for 66 yards. Senior receiver Kentron Poitier stands at 6-foot-3 and gives the Seminoles some variance in the room. Poitier has good size to box out defenders and bring down those contested catches. In his collegiate career, the Florida native has 32 receptions for 574 yards and five touchdowns. In the loss to Boston College, Poitier has three catches for 79 yards and one score. See who to back at SportsLine

How to make Memphis vs. Florida State picks

SportsLine's model is leaning Over on the total, projecting 59 points. It also says one side of the spread hits over 50% of the time. You can see the model's pick at SportsLine.

So who wins Memphis vs. Florida State, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out.