Jayden Clerveaux ran for 104 yards and a touchdown, Jordan Fuller ran for two scores and Holy Cross used the middle quarters to take control and beat Bryant 43-22 on Saturday.
Entering the second quarter trailing 16-7, Fuller reduced Holy Cross' (1-2) deficit to 16-14 scoring on an 8-yard run with 4:15 remaining before halftime.
After forcing Bryant (1-2) to punt, Holy Cross went on a four-play, 66-yard drive that ended when Joe Pesansky threw a 30-yard touchdown pass to Max Mosey.
Holy Cross added to its 21-16 lead in the third when Fuller ran it in from the 1 and Clerveaux ran it in from the 8 with 54 seconds left before the end of the third to make it 35-16.
Holy Cross ran for 201 yards on 40 carries.
Jarrett Guest threw for 141 yards, two touchdowns and an interception for Bryant.
The Crusaders lead the series 3-1.
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