Degenhardt ran 3 yards to tie the game at 21-all with 10:22 remaining and scored the Crusaders' final touchdown on a 4-yard run with 1:04 left. In between, Domenic Cozier ran 12 yards for a score, Peter Oliver sprinted 45 for another and John Smith returned an interception 42 yards for another TD.
The victory keeps Holy Cross (6-5, 4-1) a game up over second-place Lafayette, Lehigh and Bucknell, all 3-2.
Degenhardt threw for 194 yards including a touchdown. Domenic Cozier rushed for 156 on 19 carries with two scores. Ayir Asante had 119 yards receiving.
Tim DeMorat threw for 346 yards for the Rams (3-8, 1-4) with three touchdowns but had two passes intercepted. Hamze El-Zayat had 122 yards receiving and Dequece Carter 120.
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