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Big Ten rivals Michigan (5-4, 3-3) and No. 8 Indiana (9-0, 6-0) are set to square off in a highly-anticipated college football Week 11 showdown on Saturday on CBS and Paramount+. The Wolverines have been inconsistent in their national title-defending campaign, most recently falling at home to the No. 1 Oregon Ducks 38-17. Now they must visit an undefeated Hoosiers team that has dominated every opponent it has faced this season. Indiana is 8-1 against the spread, while Michigan is just 2-7 ATS. Michigan has injury concerns at cornerback with star Will Johnson (toe) ruled out and starter Jyaire Hill listed as questionable. 

Kickoff from Memorial Stadium in Bloomington, Ind., is at 3:30 p.m. ET. After opening at -10.5, the Hoosiers are now 14.5-point favorites in the latest Indiana vs. Michigan odds, while the over/under for total points scored is 48 via SportsLine consensus. Before making any Michigan vs. Indiana picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

Saturday's game can be seen live on CBS and streamed live on Paramount+, which you can now get for a 7-day free trial. Sign up right here.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 18-9 on all top-rated picks over the past six weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, the model has dialed in on Indiana vs. Michigan and just revealed its coveted betting picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football odds for the Michigan vs. Indiana matchup:

  • Indiana vs. Michigan spread: Indiana -14.5
  • Indiana vs. Michigan over/under: 48 points 
  • Indiana vs. Michigan money line: Indiana -667, Michigan +464
  • Indiana vs. Michigan picks: See picks at SportsLine
  • Indiana vs. Michigan streaming: Paramount+ (Get 7 days free)

Why Michigan can cover

The Michigan offense has left a lot to be desired this season thanks to key pieces of the championship team leaving this offseason. That means it will be up to Wink Martindale's defense to slow down an Indiana offense that has had a very manageable schedule so far this season.

Michigan is allowing just 23.3 points per game this season and has a good job holding off conference opponents Minnesota, Michigan State and USC. The Wolverines have also won each of their last three games against the Hoosiers and held Indiana to 10 or fewer points each time. Michigan prevailed 31-10 the last time these teams faced off in Bloomington. See picks at SportsLine.

Why Indiana can cover

The Wolverines may be the best team the Hoosiers have faced this season, but Indiana has tools on both sides of the ball to help it win by a wide margin. The Hoosiers offense leads the Big Ten in average yards per game (476.2) and points per game (46.6), and starting quarterback Kurtis Rourke has completed 73.3% of his passes while averaging 10.5 yards per pass. Meanwhile, the defense ranks second in yards per game allowed (261.0).

During its current undefeated run, Indiana is 8-1-0 ATS and have covered in eight straight. The Hoosiers have also hit the Over in seven of those games, scoring over 30 points each time. See picks at SportsLine.

How to make Michigan vs. Indiana picks

SportsLine's model is going Over on the total, projecting 51 combined points. It also says one side of the spread hits in over 60% of simulations. You can see the model's pick at SportsLine.

So who wins Michigan vs. Indiana, and which side of the spread hits over 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out, and don't forget to stream the game on Paramount+.