Payton threw a 35-yard touchdown to Ty James to complete a nine-play, 75-yard drive that put Mercer (2-1, 1-0) ahead 7-3. Marshall added touchdown runs of 10 and 1 yards in the second quarter for an 18-point lead.
Fred Davis added 94 yards on the ground with 18 carries for Mercer.
The Bears' defense stymied Furman (2-2, 0-1) quarterbacks Hamp Sisson who threw three interceptions and backup Jace Wilson who threw a pick.
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