A Big Ten battle takes center stage on Saturday when the No. 3 Ohio State Buckeyes host the Iowa Hawkeyes on CBS and Paramount+. The Buckeyes are coming off a 38-7 victory over Michigan State, while the Hawkeyes secured a 31-14 win over Minnesota in their last outing. Ohio State has dominated this series over the years, winning 13 of the last 15 meetings against Iowa. However, Iowa has covered the spread in two of its last three contests against the Buckeyes. 

Kickoff from Ohio Stadium is set for 3:30 p.m. ET. According to the latest Ohio State vs. Iowa odds from SportsLine consensus, the Buckeyes are favored by 18.5 points, while the over/under for total points scored is 45.5. Before making any Iowa vs. Ohio State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

Saturday's game can be seen live on CBS and streamed live on Paramount+, which you can now get for a 7-day free trial. Sign up right here.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns.

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Now, the model has dialed in on Ohio State vs. Iowa and just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football odds for the spreadmoney line and over/under:

  • Ohio State vs. Iowa spread: Ohio State -18.5
  • Ohio State vs. Iowa over/under: 45.5 points 
  • Ohio State vs. Iowa money line: Ohio State -1149, Iowa +703
  • Ohio State vs. Iowa picks: See picks at SportsLine
  • Ohio State vs. Iowa streaming: Paramount+ (Get seven days free)

Why Ohio State can cover

The Buckeyes are extremely explosive on the offensive side of the ball. Ohio State is averaging 48.8 points per game this season, which ranks fourth in the nation. The Buckeyes are averaging 227.0 rushing yards per game behind the dynamic duo of TreVeyon Henderson and Quinshon Judkins. Judkins leads the team in both rushing yards (390) and rushing touchdowns (5), while Henderson is averaging a whopping 8.9 yards per carry. 

Defensively, the Buckeyes are giving up just 6.75 points per game, which ranks first in college football. Ohio State ranks ninth in the country in passing defense, allowing only 134.8 passing yards per game. In addition, the Buckeyes have won nine consecutive games at home and are 13-3-1 against the spread in their last 17 games played in October. See picks at SportsLine.

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Why Iowa can cover

The Hawkeyes have found some rhythm offensively after suffering a 20-19 setback against Iowa State earlier this season. Iowa has scored 31 or more points in each of its last two games behind an effective rushing attack. In last week's victory over Minnesota, running back Kaleb Johnson recorded 21 carries for 206 yards and three touchdowns. 

For the season, Johnson has racked up 685 rushing yards and nine rushing touchdowns. He's scored at least two rushing touchdowns in every game this season and he'll likely be heavily featured in Iowa's offensive game plan on Saturday. Defensively, the Hawkeyes are giving up only 62.0 rushing yards per game. See picks at SportsLine.

How to make Iowa vs. Ohio State picks

SportsLine's model is leaning Over on the total, projecting 46 combined points. It also says one side of the spread hits in well over 50% of simulations. You can see the model's pick at SportsLine.

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So who wins Ohio State vs. Iowa, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out, and don't forget to stream Iowa vs. Ohio State on Paramount+.