The No. 15 Oklahoma Sooners (2-0) will play the final game before their SEC slate begins when they host the Tulane Green Wave (1-1) on Saturday afternoon. Oklahoma opened the season with a 51-3 win over Temple before squeaking past Houston in a 16-12 final last week. The Sooners will play their first conference game as members of the SEC against No. 7 Tennessee in Week 4. Tulane has another chance to take down a ranked team following its 34-27 loss to then-No. 17 Kansas State. 

Kickoff is set for 3:30 p.m. ET on Saturday at Gaylord Family-Oklahoma Memorial Stadium. Oklahoma is favored by 13.5 points in the latest Oklahoma vs. Tulane odds, while the over/under is 49.5 points, per SportsLine consensus. Before entering any Tulane vs. Oklahoma picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns.

The model has set its sights on Tulane-Oklahoma. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • Oklahoma vs. Tulane spread: Oklahoma -13.5
  • Oklahoma vs. Tulane over/under: 49.5 points
  • Oklahoma vs. Tulane money line: Oklahoma -617, Tulane +442
  • Oklahoma vs. Tulane picks: See picks here

Why Oklahoma can cover

Oklahoma might be coming off a lackluster performance in Week 2, but it cruised to a 51-3 win over Temple in its opener. Sophomore quarterback Jackson Arnold threw for 141 yards and four touchdowns in that win, including three to Purdue transfer Deion Burks. Arnold finished with 174 yards and two touchdowns in last week's win over Houston, but Oklahoma's defense held the Cougars to a 4 of 15 mark on third down. 

Wide receiver Nic Anderson, who had 10 touchdown receptions last season, could make his season debut on Saturday as he continues recovering from a hamstring injury. Tulane has a young quarterback of its own in redshirt freshman Darian Mensah, who threw an interception and lost a fumble in the fourth quarter against Kansas State. The Sooners have forced eight turnovers through their first two games, which does not bode well for Tulane's young quarterback. See which team to pick here. 

Why Tulane can cover

Tulane has made a habit of taking big-name programs down to the wire in recent seasons, including a 40-35 Oklahoma victory in the most recent meeting between these teams (2021). The Green Wave pushed Kansas State throughout last week's game, ultimately covering the spread as 8.5-point underdogs. Mensah threw for 342 yards and two touchdowns, while sophomore running back Makhi Hughes rushed for 128 yards and a score. 

Oklahoma finished with just 249 yards of total offense last week, as Arnold completed 19 of 32 passes with an interception. The Sooners are already down to their third center of the season, as starter Branson Hickman (ankle) and backup Geirean Hatchett (biceps) have both suffered injuries. Their rushing attack and pass protection both took a hit in last week's game against Houston. See which team to pick here. 

How to make Oklahoma vs. Tulane picks

The model has simulated Tulane vs. Oklahoma 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

So who wins Oklahoma vs. Tulane, and which side of the spread is hitting 60% of the time? Visit SportsLine now to see which side of the Tulane vs. Oklahoma spread to jump on, all from the advanced computer model that's up over $2,000 on its top-rated college football spread picks since its inception, and find out.