Ole Miss vs. Tulane prediction, odds: 2025 College Football Playoff first round picks by proven model

The 11th-seeded Tulane Green Wave will take on No. 6 Ole Miss Rebels in a 2025 College Football Playoff first-round matchup on Saturday. Tulane won the AAC title with a 34-21 win over North Texas on Dec. 5, while Ole Miss finished the regular season with a 38-19 win at Mississippi State. The Green Wave (11-2), who finished 7-1 in the American, are 2-1 against ranked opponents this season. The Rebels (11-1), who finished tied for first in the SEC at 7-1, are 2-1 against ranked foes in 2025. These teams met in the regular season on Sept. 20 and Ole Miss won 45-10, easily covering as 10.5-point favorites. Jon Sumrall, who has taken the Florida job, will still coach for Tulane in this game. Pete Golding has taken over for Ole Miss after Lane Kiffin's departure to LSU. 

Kickoff from Vaught-Hemingway Stadium in Oxford, Miss., is at 3:30 p.m. ET. The Rebels are 17-point favorites in the latest Tulane vs. Ole Miss odds, while the over/under for total points scored is 57.5. Before making any Ole Miss vs. Tulane picks, check out the college football predictions from the SportsLine Projection Model. 

New users can target the DraftKings promo code, which offers $200 in bonus bets if your $5+ bet wins:

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line picks since the beginning of the 2024 season. Anybody following those college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Tulane vs. Ole Miss. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Ole Miss vs. Tulae:

New users can also check out the latest FanDuel promo code and get $250 in bonus bets at FanDuel if your $5 bet wins. 

Why Ole Miss can cover

The Rebels are led by senior quarterback Trinidad Chambliss. In 12 games, he has completed 65.5% of his passes for 3,016 yards and 18 touchdowns with three interceptions. He has also rushed 118 times for 470 yards (4.0 average) and six touchdowns. In the September win over Tulane, he completed 17 of 27 passes for 307 yards and two touchdowns.

Sophomore running back Kewan Lacy powers the Rebels' rushing attack. In 12 games, he has carried 258 times for 1,279 yards (5.0 average) and 20 touchdowns. In the win over Mississippi State, he carried 27 times for 143 yards and one touchdown. In a 34-24 win over Florida on Nov. 15, he carried 31 times for 224 yards and three scores. See which team to back at SportsLine.

Why Tulane can cover 

Junior quarterback Jake Retzlaff leads the Green Wave offense. In 13 games, he has completed 62.4% of his passes for 2,862 yards and 14 touchdowns with six interceptions. He has also carried 118 times for 610 yards (5.2 average) and 16 touchdowns. In a 38-32 win at Memphis on Nov. 7, he completed 16 of 23 passes for 332 yards and three touchdowns, while rushing 10 times for 43 yards and a score.

The top pass catcher is junior wide receiver Shazz Preston. He leads the team with 38 receptions for 598 yards (15.7 average) and four touchdowns. In the win over Memphis, he caught three passes for 85 yards and two touchdowns, including a long of 65. In a 24-17 win over Army on Oct. 18, he caught five passes for 86 yards and a score. See which team to back at SportsLine.

How to make Tulane vs. Ole Miss picks

SportsLine's model is going Over on the total. It also says one side of the spread hits in well over 50% of simulations. You can see the model's pick at SportsLine.  

So who wins Ole Miss vs. Tulane, and which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Tulane vs. Ole Miss spread to jump on, all from the advanced model that's up on its top-ranked money-line picks, and find out.