An ACC vs. SEC showdown takes center stage when the No. 14 Ole Miss Rebels match up against the Duke Blue Devils in the 2025 Gator Bowl on Thursday, Jan. 2. Both teams will look to secure their 10th win of the season with a victory on Thursday. Lane Kiffin's squad had lofty aspirations this season, but fell just short of the College Football Playoff. The Blue Devils, meanwhile, were one of the biggest surprises in 2024 and enter Thursday's tilt having won three straight. Duke will be without starting quarterback Maalik Murphy, who entered the transfer portal and signed with Oregon State.
Kickoff is set for 7:30 p.m. ET on Thursday at EverBank Stadium in Jacksonville. Ole Miss is favored by 17.5 points in the latest Ole Miss vs. Duke odds via SportsLine consensus, while the over/under is 51.5 points. Before entering any Duke vs. Ole Miss picks or 2025 Gator Bowl bets, you'll want to see the college football predictions and betting advice from the proven computer model at SportsLine.
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is 43-35 on top-rated picks during the 2024 season. It also nailed all four winners in the first round of the College Football Playoff. Anyone following at sportsbooks and on betting apps has seen impressive returns.
Now, the model has set its sights on Ole Miss vs. Duke in the Gator Bowl 2025. You can head to SportsLine now to see the model's picks. Here are several college football betting lines for Duke vs. Ole Miss:
- Ole Miss vs. Duke spread: Ole Miss -17.5
- Ole Miss vs. Duke over/under: 51.5 points
- Ole Miss vs. Duke money line: Ole Miss -840, Duke +573
- Ole Miss vs. Duke picks: See picks at SportsLine
- Ole Miss vs. Duke streaming: FuboTV (Try for free)
Why Ole Miss can cover
The Rebels are loaded with playmakers on both sides of the ball. Offensively, Ole Miss is led by quarterback Jaxson Dart. The senior signal caller threw for 3,875 yards, 25 touchdowns and six interceptions this season. He's also been effective as a runner, recording 112 carries for 452 yards and three touchdowns.
Ole Miss is stacked with dynamic difference-makers on defense. The Rebels had five defensive linemen make the All-SEC team at season's end, including interior lineman Walter Nolen. Nolen has recorded four of his 6.5 sacks over his last four games and will be a coveted prospect in the upcoming NFL Draft. In addition, the Rebels are 6-1 against the spread in their past seven games against an opponent from the ACC. See which team to pick here.
Why Duke can cover
The Blue Devils will certainly miss Murphy at quarterback, but they still have a strong duo at receiver in Jordan Moore and Eli Pancol. Moore led the team with 798 receiving yards, while Pancol led the way in receptions (55) and receiving touchdowns (9). They'll be reliable targets for quarterback Henry Belin IV, who has seen limited playing time this season.
Duke has also been profitable for bettors all season long. The Blue Devils are 5-1 against the spread in their last six games and 7-1-1 ATS in their previous nine matchups when playing as the underdog. See which team to pick here.
How to make Duke vs. Ole Miss picks
The model has simulated Ole Miss vs. Duke 10,000 times and the results are in. The model is leaning Under on the total, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the model's pick at SportsLine.
So who wins Ole Miss vs. Duke in the 2025 Gator Bowl, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out.
