Penn State vs. Clemson prediction, odds, time: 2025 Pinstripe Bowl picks by proven model

The Penn State Nittany Lions will take on the Clemson Tigers in the 2025 Pinstripe Bowl on Saturday, Dec. 27. The Nittany Lions (6-6), who finished tied for 12th in the Big Ten at 3-6, finished the season on a three-game winning streak. The Tigers (7-5), who tied for seventh in the ACC at 4-4, finished the regular season with four wins in a row. Both rosters will be a shell of themselves with nearly 30 Clemson players out for various reasons, while Penn State will be missing plenty as well. Running back Nicholas Singleton is one of the more notable absences for Penn State, while Clemson will be without receiver Antonio Williams and defensive linemen Peter Woods and T.J. Parker, among many others. Both quarterbacks are slated to play however, with Cade Klubnik leading Clemson and Ethan Grunkemeyer, who took over after Drew Allar tore his ACL, starting for Penn State. 

Kickoff from Yankee Stadium in New York is at noon ET. The Tigers are 2.5-point favorites in the latest Penn State vs. Clemson odds, while the over/under for total points scored is 47.5. Before making any Clemson vs. Penn State picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. 

Now, the model has set its sights on Penn State vs. Clemson. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Clemson vs. Penn State:

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How to make Penn State vs. Clemson picks

After 10,000 simulations, SportsLine's model is going Under (47.5) on the total. The Under has hit in four straight Clemson games, while the Tigers were 8-4 to the Under this season. 

Stars from both side of the ball are missing, but Penn State's losses on the offensive line could be particularly detrimental to the Nittany Lions' ability to move the ball. The model has PSU quarterback Ethan Grunkemeyer passing for fewer than 170 yards. Clemson, meanwhile, is missing a lot at receiver and on the O-line. The model projects 46 combined points as the Under hits nearly 60% of the time. 

The model also says one side of the spread hits nearly 60% of the time. You can see the model's pick at SportsLine.  

So who wins Penn State vs. Clemson, and which side of the spread hits in nearly 60% of simulations? Visit SportsLine now to see which side of the Penn State vs. Clemson spread to jump on, all from the advanced model that's simulated this game 10,000 times, and find out.