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The Pittsburgh Panthers are set to take on the Massachusetts Minutemen at 4 p.m. ET on Saturday at Heinz Field. Pitt is coming off a 6-5 season in 2020 and returns Kenny Pickett at quarterback and dynamic sophomore wide receiver Jordan Addison. UMass posted an 0-4 record in its abbreviated 2020 season, but brought in several transfers, including former Colorado quarterback Tyler Lytle.  

The Panthers are favored by 38 points in the latest Pittsburgh vs. Massachusetts odds from Caesars Sportsbook, and the over-under is set at 56. Before locking in any UMass vs. Pittsburgh picks, you need to see the college football picks and predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Pittsburgh vs. Massachusetts and just revealed its high-level analysis. You can head to SportsLine now to see its picks. Here are several college football odds for Pitt vs. UMass:

  • Pittsburgh vs. UMass spread: Pittsburgh -38
  • Pittsburgh vs. UMass over-under: 56 points

What you need to know about the Pittsburgh Panthers 

Pitt was on the positive side of .500 (6-5) last season and is hoping to kick off an even more successful year. Last year, the Panthers were the best in the nation in sacks, finishing the 2020 season with 46. Their dominance on the defensive side of the ball should continue in 2021 with several starters returning. Offensively, Pickett has an All-America candidate at wide receiver in Addison, who finished last season with 666 receiving yards and four touchdowns.

What you need to know about the Massachusetts Minutemen

UMass has set its aspirations higher this year after an uninspired 0-4 record last fall. The Minutemen ranked worst in the nation in respect to rushing yards allowed per game last season, but added 12 key transfers this offseason and should be a much stronger team on both sides of the ball in 2021.

How to make Pittsburgh vs. Massachusetts picks

The model has simulated Pittsburgh vs. Massachusetts 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Pittsburgh vs. UMass? And which side of the spread hits nearly 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks, and find out.