USATSI

The No. 12 Clemson Tigers and No. 15 South Carolina Gamecocks will play their most important rivalry game in recent years when they square off on Saturday afternoon during the Week 14 college football schedule. Both teams got back into the College Football Playoff discussion following multiple upsets last week, and Clemson is a 2.5-point favorite in the Week 14 college football odds. There are a pair of other ranked vs. ranked matchups this weekend, as No. 18 Iowa State (-2.5) hosts No. 24 Kansas State and No. 20 Texas A&M (+5.5) faces No. 3 Texas. Should you target any of those games with your Week 14 college football bets?

Other important Week 14 college football spreads include No. 5 Notre Dame (-7.5) at USC, No. 2 Ohio State (-20.5) vs. Michigan and No. 6 Miami (-11) at Syracuse. Notre Dame is coming off a blowout win over Army, and it can essentially secure its spot in the College Football Playoff with a win on Saturday. Before making any Week 14 college football picks and college football score predictions, you need to see the college football against the spread, over/under and money-line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has hit a whopping 2,073 4.5- and 5-star NFL picks since the start of last season. Anyone who has followed it is way up at their best sports betting app and favorite betting sites

For Week 14 college football betting, the AI PickBot has evaluated the college football odds and provided college football betting picks for every game. You can only see the AI predictions for the Week 14 college football schedule here.

Top Week 14 college football AI picks

After analyzing every game in Week 14, the AI PickBot says the No. 9 SMU Mustangs (-13.5, 57.5) cover comfortably at home against the California Golden Bears in a 3:30 p.m. ET kickoff on Saturday. SMU lost to BYU in early September, but it has rattled off an eight-game winning streak since then to clinch its spot in the ACC title game. The Mustangs are not in a letdown spot this week though, as a loss on Saturday would likely knock them out of the College Football Playoff picture. 

Quarterback Kevin Jennings threw for a career-high 323 yards and two touchdowns while rushing for another in a 33-7 win over Virginia last week. Jennings leads an offense that has scored more than 30 points in seven of its last eight games. The AI PickBot has identified value on SMU, projecting the Mustangs to win by an average final score of 38-22 to earn an A-rating. See its other Week 14 college football predictions and football picks at SportsLine.

How to make Week 14 college football picks

In addition, the AI PickBot has generated 18 more A-rated spread picks for Week 14. You need to see the AI PickBot's college football picks before making any Week 14 college football bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 14 college football game, and which A-rated picks should you target now? Visit SportsLine now to see the top college football picks against the spread, over/under, and on money line, all from the brand-new SportsLine AI PickBot that has nailed 2,073 top-rated NFL picks since the start of last season.