The South Carolina Gamecocks will take on the Troy Trojans at 3:30 p.m. ET on Saturday at Williams-Brice Stadium. South Carolina is 2-2 overall and 1-1 at home, while Troy is 2-2 overall and 1-1 on the road. The two programs have met three times before with South Carolina taking all three contests.

South Carolina is 3-1 against the spread this season, while Troy is 2-2 against the number. The Gamecocks are favored by 6.5-points in the latest South Carolina vs. Troy odds from Caesars Sportsbook, and the over-under is set at 43.5. Before entering any Troy vs. South Carolina picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, it also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Carolina vs. Troy. You can head to SportsLine to see its picks. Here are several college football odds for South Carolina vs. Troy:

  • South Carolina vs. Troy spread: South Carolina -6.5
  • South Carolina vs. Troy over-under: 43.5 points
Featured Game | South Carolina Gamecocks vs. Troy Trojans

What you need to know about South Carolina

The Gamecocks didn't finish too far behind, but the squad still lost 16-10 to the Kentucky Wildcats last Saturday. No one had a standout game offensively for South Carolina, but QB Luke Doty led the way with one touchdown. Doty's lone touchdown pass went to Jalen Brooks as he caught four passes for 63 yards in the contest.

Jaylan Foster had a big game defensively in the loss. He registered 12 total tackles and had an interception to help limit Kentucky to just 332 total yards and 16 points. South Carolina forced a total of three turnovers in the game and has now generated multiple turnovers in all four games it's played this season.

What you need to know about Troy

Meanwhile, Troy came up short against the Louisiana-Monroe Warhawks last Saturday, falling 29-16. Quarterback Taylor Powell had a big game in the loss, completing 35-of-49 pass attempts for 311 yards and two touchdowns. He's now completing 69.2 percent of his passes for 1,008 yards and seven touchdowns with three interceptions this season.

Sophomore receiver Tez Johnson could pose matchup problems with his short-area quickness from the inside. He's caught 24 passes for 250 yards and a touchdown this season. Meanwhile, Luke Whittemore has been the big-play receiver with 14 catches for 253 yards and a touchdown.

How to make Troy vs. South Carolina picks

The model has simulated South Carolina vs. Troy 10,000 times and the results are in. We can tell you that the model is leaning under and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins South Carolina vs. Troy? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.