The Vanderbilt Commodores (6-3) will make their case for a spot in next week's College Football Playoff rankings when they host the South Carolina Gamecocks (5-3) on Saturday afternoon. Vanderbilt is coming off its fourth upset win of the season, beating Auburn as an 8-point road underdog. South Carolina is coming off an impressive performance of its own, blowing out then-No. 10 Texas A&M by 24 points. The Gamecocks rolled to a 47-6 win over the Commodores last season. 

Kickoff is set for 4:15 p.m. ET on Saturday at FirstBank Stadium. South Carolina is favored by 4.5 points in the latest Vanderbilt vs. South Carolina odds, while the over/under is 45.5 points, per SportsLine consensus. Before entering any South Carolina vs. Vanderbilt picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 18-9 on all top-rated picks over the past six weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has set its sights on South Carolina vs. Vanderbilt. You can head to SportsLine to see its picks. Here are several college football betting lines for the Vanderbilt vs. South Carolina game:

  • Vanderbilt vs. South Carolina spread: South Carolina -4.5
  • Vanderbilt vs. South Carolina over/under: 45.5 points
  • Vanderbilt vs. South Carolina money line: South Carolina -189, Vanderbilt +156
  • Vanderbilt vs. South Carolina picks: See picks here
  • Vanderbilt vs. South Carolina streaming: FuboTV (Try for free)

Why Vanderbilt can cover

Vanderbilt has won four of its last five games, including a trio of upset wins against conference opponents. The Commodores took down then-No. 1 Alabama and Kentucky in back-to-back games before falling to then-No. 5 Texas by just a field goal. They bounced back with a 17-7 win at Auburn last week, pulling off their fourth upset of the season. 

Senior quarterback Diego Pavia has 1,677 passing yards, 15 touchdowns and just three interceptions while rushing for 563 yards and four scores. The Commodores have been consistently profitable for their bettors this season, covering the spread in five of their last six games. They are available as underdogs again this week, and there is nothing suggesting a letdown performance on Saturday. See which team to pick here. 

Why South Carolina can cover

South Carolina is on an impressive run of its own, covering the spread in three straight games. The Gamecocks were 21.5-point underdogs in their 27-25 loss at then-No. 7 Alabama in mid-October before blowing out Oklahoma and then-No. 10 Texas A&M. They were 3-point underdogs against the Aggies, who were sitting alone in solo first place in the SEC standings prior to that game. 

Freshman quarterback LaNorris Sellers had 244 passing yards and two touchdowns against the Aggies, while senior running back Raheim Sanders rushed for 144 yards and two scores. The Gamecocks are strong defensive team that can contain Pavia and slow down Vanderbilt's offense in this matchup. They have also dominated this series, winning 15 consecutive games. See which team to pick here. 

How to make Vanderbilt vs. South Carolina picks

The model has simulated South Carolina vs. Vanderbilt 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Vanderbilt vs. South Carolina, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the South Carolina vs. Vanderbilt spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.