Matthews was removed from Tuesday's game against the Mariners with an apparent leg injury, Chandler Rome of The Athletic reports.
Matthews came up limping after making a diving catch in center field during the second inning of Tuesday's game, and he was eventually pulled in the sixth. The fact that he was able to remain in the game for a while after making the play is an encouraging sign, though the Astros will likely provide more information on his health in the near future.