The Astros designated Salazar for assignment Thursday, Brian McTaggart of MLB.com reports.
Salazar has gone just 1-for-18 in the majors while receiving limited opportunities, so the Astros will cast him off the roster and replace him with Collin Price, who was selected from Triple-A Sugar Land in a corresponding move. Salazar, 30, doesn't have minor-league options remaining and carries just a .512 OPS in his big-league career, making him likely to pass through waivers unclaimed.