Keuchel (11-11) took the loss Wednesday, coughing up five runs on six hits and two walks over five innings while striking out three as the Astros were routed 9-0 by the Mariners.
It marked the third time in his last 10 outings that the southpaw was tagged for five runs, but Keuchel's provided Houston with a quality start in the other seven. Barring any last-minute rotation shuffles to prepare for the playoffs, he's lined up for a potentially productive two-start week to close out the regular season, heading to Toronto on Tuesday before wrapping up the campaign in Baltimore on Sunday.