The Astros reinstated Wesneski (elbow) from the injured list ahead of his start Wednesday against the Angels.
Wesneski's start will mark his first appearance on a big-league mound since May 2025, as he's been on the shelf for more than a year recovering from Tommy John surgery. The right-hander has made five appearances in the minor leagues over the past month, however, turning in a 2.25 ERA and 1.00 WHIP alongside a 21:4 K:BB in 20 innings. Miguel Ullola was optioned to Triple-A Sugar Land in a corresponding move.