The Astros recalled Loperfido from Triple-A Sugar Land on Tuesday.
Loperfido was optioned last week after recovering from a quadriceps strain, but he's now back in the big leagues as a replacement on the active roster for LaMonte Wade (hamstring), who was placed on the injured list. The 27-year-old Loperfido will be among a handful of players in the mix for starts in left field for the Astros.