Altuve (foot) is out of the lineup for Wednesday's tilt in San Francisco.
Altuve departed Tuesday's 4-1 loss after being hit on the left foot by a pitch. Astros manager Joe Espada said Wednesday that Altuve remains sore and will be evaluated by team doctors when the team returns home this weekend, according to Matt Kawahara of the Houston Chronicle. Nick Allen will fill in for Altuve at second base Wednesday.