Altuve is not in the lineup for Wednesday's game against the Mariners, Brian McTaggart of MLB.com reports.
It's a rare day off for Altuve, who will take a seat for just the third time since the All-Star break. The 27-year-old second baseman is in the midst of a monster year, slashing .351/.412/.557 with 21 homers and 31 stolen bases in 133 games, so look for him to return to the lineup following the Astros' off-day Thursday. Marwin Gonzalez is starting at the keystone in his stead.