Spence went 1-for-3 with a walk in a 3-2 loss to Baltimore on Friday.
Spence was called up to make his big-league debut in center field after Brice Matthews (knee) was placed on the 10-day injured list. The 23-year-old Spence went on to pick up his first hit in the seventh inning off Grant Wolfram. Spence should continue to see playing time in center field for Houston.