Spence will start Friday in Kansas City, Martin Gallegos of MLB.com reports.
It will be the first major-league start for Spence, who has posted a 4.26 ERA and 22:7 K:BB over 25.1 innings covering 11 relief appearances. The Rule 5 pick will be pitching on three days' rest after allowing two runs over two-thirds of an inning Monday in Houston, so he likely won't be able to pitch deep into Friday's contest. Spence has gone three-plus frames in six of his relief appearances, including a season-long 4.2-inning outing May 5 versus the Marlins. He could wind up piggybacking with Kyle Muller, who is also available to work multiple innings.