Biggio is not in the lineup for Game 2 of Wednesday's doubleheader at Boston.
Biggio started the matinee and went 1-for-3 with a pair of strikeouts. The 26-year-old has struggled since the All-Star break, going 5-for-27 with a solo home run, two walks and an additional run scored in nine games. Santiago Espinal will start at third base in the nightcap.