Leone was optioned to Triple-A Buffalo on Saturday, Shi Davidi of Sportsnet reports.
It ends a short-but-productive stay in the majors for the right-hander, who was brought up to fill in for the injured Roberto Osuna (neck). Leone relieved Francisco Liriano in Friday's loss, holding the Rays to one run over 2.2 innings and recording three strikeouts. He'll have a chance to build on his strong performance in the minors, but could certainly be in line for another call-up later this season.