The Cardinals activated O'Brien (forearm) from the 60-day injured list Sunday and optioned him to Triple-A Memphis.
O'Brien has been sidelined since he suffered a flexor strain Opening Day against the Dodgers, and he'll head to the minors now that he's healthy. The 29-year-old allowed two earned runs with a 5:4 K:BB over eight innings during his rehab assignment with Memphis.
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