Gomes was scratched from Tuesday's lineup against the Reds due to left oblique tightness, Meghan Montemurro of the Chicago Tribune reports.
The 34-year-old was set to serve as Chicago's designated hitter but is now out of the starting nine with the oblique issue. Starting catcher Willson Contreras (hamstring) is also banged up, leaving P.J. Higgins to work behind the plate.