Hultzen announced his retirement Thursday, Barry Svrluga of The Washington Post reports.
Hultzen was part of the Cubs' 60-man player pool in 2020 but never reached the majors during the season. The southpaw was the second overall pick in the 2011 first-year player draft, but several shoulder injuries derailed his career. He made just six relief appearances in the majors during the 2019 season, tossing 3.1 scoreless innings with five strikeouts.