The Diamondbacks placed Santana on the 10-day injured list Tuesday with a right adductor strain.
Santana suffered the injury in Sunday's game versus Atlanta and will need at least the next week-and-a-half to recuperate. With Pavin Smith (elbow) also shelved, the Diamondbacks' first-base and designated-hitter depth has thinned out. Ildemaro Vargas is at first base and Adrian Del Castillo is at DH on Tuesday against the Mets.