The Diamondbacks transferred Santana (thigh) from the 10-day injured list to the 60-day IL on Monday.
The transaction frees up space on the 40-man roster for first baseman/designated hitter Pavin Smith (elbow), who was reinstated from the 60-day IL. Santana was pulled off his rehab assignment in mid-May after suffering a setback with his right adductor strain and remains without a timeline for a return.