The Giants placed Estrada on the 10-day injured list Friday with a sprained left wrist.
Estrada landed on the injured list in late June due to a left wrist sprain, and the same injury will now force him back onto the IL roughly one month later. He was able to return to the active roster after 11 days following his previous IL stint, though it's unclear if he'll require a longer absence this time around. Casey Schmitt was recalled from Triple-A Sacramento to provide infield depth, and he'll likely split reps at second base with Brett Wisely until Estrada returns.