The Guardians designated Brogdon for assignment Wednesday.
A 40-man spot was needed for the return of Shawn Armstrong (calf) from the 60-day IL, and Brogdon is the odd man out. Brogdon made a lone appearance during his latest stint with the big club, throwing a scoreless two-thirds of an inning back on Sept. 14. The right-hander has put up a 5.06 ERA, 1.12 WHIP and 15:3 K:BB in 16 major-league appearances (16 innings) this season.