Brito started at second base and went 2-for-4 with a double in Tuesday's 2-1 win over the Royals.
The 24-year-old infield prospect had a whirlwind 24 hours. He was in Worcester (Mass.) with Triple-A Columbus on Monday when the Guardians called him up to replace shortstop Gabriel Arias (hamstring), who was placed on the 10-day injured list. Brito hopped an early flight Tuesday morning to Cleveland and made his MLB debut in the afternoon. With Arias out of action, Brayan Rocchio moved from second base to short, which opened a position for the switch-hitting Brito, who could step into a platoon at the keystone.