The Guardians designated Barlow for assignment Sunday.
Barlow has struggled since the start of August with 11 earned runs allowed across 11.2 innings, and it will cost him his place on the roster. The veteran right-hander had a 3.12 ERA in 50 outings this season prior to that stretch, so he could land somewhere for the final weeks of the season, though he won't be playoff eligible with a different organization.