Santana went 2-for-4 with a homer, two runs scored and two RBI in Monday's 7-4 win over the Rays.
Santana was a key part of the balanced Indians attack, pulling them to within one in the sixth before some of his teammates' late-inning heroics propelled them to victory. He hit just 19 homers last season, but has already gone yard 15 times in 2016.