Perez is being evaluated for a sore right shoulder, Zack Meisel of The Athletic reports.
The 31-year-old apparently sustained the injury during Game 1 of Tuesday's doubleheader, though he was never removed from the contest. Sandy Leon started the nightcap -- and was likely to do so regardless of the injury situation -- but Cleveland did call up Beau Taylor to bolster the team's catching depth. Perez's status is expected to be updated Wednesday.