Paxton was recalled from Triple-A Tacoma Wednesday and will start against the Padres, Greg Johns of MLB.com reports.
Paxton will take Felix Hernandez's spot in the rotation until he is back from the 15-day DL. The former fourth-round pick has posted a 3.97 ERA and 1.17 WHIP to go along with an impressive 9.5 K/9 through 10 starts at Triple-A this season.