The Marlins designated Ramirez for assignment Tuesday.
The right-hander was optioned to Triple-A Jacksonville in late August and has now lost his place on the 40-man roster. Ramirez posted a 6.97 ERA in 15 outings for Miami this season but pitched well for Jacksonville with a 3.76 ERA, 1.17 WHIP and 51:16 K:BB across 40.2 innings.