Manager Terry Collins confirmed Monday that Milone will start Wednesday against the Giants, Marc Carig of Newsday reports.
Milone will slide into the spot vacated by Rafael Montero, as expected. He posted a decent 3.92 ERA over 23 starts for the Twins in 2015, but Milone has served up 21 home runs and a 5.88 ERA over 90.1 innings in 2016 and 2017 combined.